CUED Publications database

Specific hippocampal representations are linked to generalized cortical representations in memory.

Yu, JY and Liu, DF and Loback, A and Grossrubatscher, I and Frank, LM (2018) Specific hippocampal representations are linked to generalized cortical representations in memory. Nat Commun, 9. 2209-.

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Abstract

Memories link information about specific experiences to more general knowledge that is abstracted from and contextualizes those experiences. Hippocampal-cortical activity patterns representing features of past experience are reinstated during awake memory reactivation events, but whether representations of both specific and general features of experience are simultaneously reinstated remains unknown. We examined hippocampal and prefrontal cortical firing patterns during memory reactivation in rats performing a well-learned foraging task with multiple spatial paths. We found that specific hippocampal place representations are preferentially reactivated with the subset of prefrontal cortical task representations that generalize across different paths. Our results suggest that hippocampal-cortical networks maintain links between stored representations for specific and general features of experience, which could support abstraction and task guidance in mammals.

Item Type: Article
Uncontrolled Keywords: Animals Behavior, Animal CA1 Region, Hippocampal Electrodes, Implanted Generalization (Psychology) Male Memory Nerve Net Neurons Prefrontal Cortex Rats Rats, Long-Evans Reward
Subjects: UNSPECIFIED
Divisions: Div F > Control
Depositing User: Cron Job
Date Deposited: 19 Jun 2018 01:57
Last Modified: 21 Nov 2019 02:08
DOI: 10.1038/s41467-018-04498-w