CUED Publications database

Mechanical properties of RBCs under oxidative stress measured by optical tweezers

Liu, J and Zhang, F and Zhu, L and Chu, D and Qu, X (2019) Mechanical properties of RBCs under oxidative stress measured by optical tweezers. Optics Communications, 442. pp. 56-59. ISSN 0030-4018

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© 2019 Elsevier B.V. Mechanical characterization of human red blood cells (RBC) is crucial to the study of the pathology, drug screening, clinical diagnosis, and treatment of Parkinson's disease. Oxidative stress has been found to be a dominant factor among the causes of Parkinson's disease. This paper proposes a method for measuring cell mechanical properties using optical tweezers. By measuring the membrane shear modulus of RBCs treated with hydrogen peroxide (H 2 O 2 ) at different concentrations, mechanical properties of RBCs under oxidative stress were analyzed. The experimental results reveal that increased membrane shear modulus and decreased cell deformability are commensurate with increasing concentrations of H 2 O 2 . This proposal will benefit both basic research and clinical applications in the field of Parkinson's disease research. The results will also provide a guideline for measuring the mechanical properties of other cells.

Item Type: Article
Divisions: Div B > Photonics
Depositing User: Cron Job
Date Deposited: 01 Apr 2019 20:06
Last Modified: 25 Feb 2021 08:16
DOI: 10.1016/j.optcom.2019.02.060