CUED Publications database

Qualitative behavior and robustness of dendritic trafficking

Aljaberi, S and O'Leary, T and Forni, F Qualitative behavior and robustness of dendritic trafficking. (Unpublished)

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Abstract

The paper studies homeostatic ion channel trafficking in neurons. We derive a nonlinear closed-loop model that captures active transport with degradation, channel insertion, average membrane potential activity, and integral control. We study the model via dominance theory and differential dissipativity to show when steady regulation gives way to pathological oscillations. We provide quantitative results on the robustness of the closed loop behavior to static and dynamic uncertainties, which allows us to understand how cell growth interacts with ion channel regulation.

Item Type: Article
Uncontrolled Keywords: q-bio.SC q-bio.SC
Subjects: UNSPECIFIED
Divisions: Div F > Control
Depositing User: Cron Job
Date Deposited: 26 Sep 2019 03:04
Last Modified: 24 Oct 2019 13:27
DOI: