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Graphene Oxide–Based Nanocomposite for Sustained Release of Cephalexin

Katuwavila, NP and Amarasekara, Y and Jayaweera, V and Rajaphaksha, C and Gunasekara, C and Perera, IC and Amaratunga, GAJ and Weerasinghe, L (2020) Graphene Oxide–Based Nanocomposite for Sustained Release of Cephalexin. Journal of Pharmaceutical Sciences, 109. pp. 1130-1135. ISSN 0022-3549

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A sustained-release carrier system for the drug cephalexin (CEF) using functionalized graphene oxide is reported. PEGylation of GO (GO-PEG) and successful loading of CEF into PEGylated graphene oxide (GO-PEG-CEF) nanoconjugate are confirmed by Fourier transform infrared spectroscopy, Raman spectroscopy, and thermogravimetric analysis. Encapsulation efficiency of 69% and a loading capacity of 19% are obtained with the optimized formulation of GO-PEG-CEF. In vitro CEF release profiles show an initial burst release followed by a more sustained release over a 96 h period with cumulative release of 80%. The half maximal inhibitory concentration (IC50) values have both dose- and time-dependent antibacterial activity for GO-PEG-CEF against both gram-positive and gram-negative bacteria while pure CEF showed only dose-dependent antibacterial activity. The minimum inhibitory concentration values of GO-PEG-CEF are 7.8 and 3.9 μg/mL against S. aureus and B. cereus, respectively, while it is 10 μg/mL with pure CEF against both gram-positive bacteria. This confirms the enhanced antibacterial activity of GO-PEG-CEF over pure CEF against gram-positive bacteria. These findings therefore show GO-PEG-CEF is promising as a sustained-release nanoantibiotic system for effective treatment against S. aureus and B. cereus infections.

Item Type: Article
Depositing User: Cron Job
Date Deposited: 29 Jan 2020 20:48
Last Modified: 13 Apr 2021 10:29
DOI: 10.1016/j.xphs.2019.09.022