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Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB

Mikhaylov, R and Wu, F and Wang, H and Clayton, A and Sun, C and Xie, Z and Liang, D and Dong, Y and Yuan, F and Moschou, D and Wu, Z and Shen, MH and Yang, J and Fu, Y and Yang, Z and Burton, C and Errington, RJ and Wiltshire, M and Yang, X (2020) Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB. Lab on a Chip, 20. pp. 1807-1814. ISSN 1473-0197

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Abstract

Acoustofluidics has been increasingly applied in biology, medicine and chemistry due to its versatility in manipulating fluids, cells and nano-/micro-particles. In this paper, we develop a novel and simple technology to fabricate a surface acoustic wave (SAW)-based acoustofluidic device by clamping electrodes made using a printed circuit board (PCB) with a piezoelectric substrate. The PCB-based SAW (PCB-SAW) device is systematically characterised and benchmarked with a SAW device made using the conventional photolithography process with the same specifications. Microparticle manipulations such as streaming in droplets and patterning in microchannels were demonstrated in the PCB-SAW device. In addition, the PCB-SAW device was applied as an acoustic tweezer to pattern lung cancer cells to form three or four traces inside the microchannel in a controllable manner. Cell viability of ~97% was achieved after acoustic manipulation using the PCB-SAW device, which proved its ability as a suitable tool for acoustophoretic applications.

Item Type: Article
Subjects: UNSPECIFIED
Divisions: UNSPECIFIED
Depositing User: Unnamed user with email sms67@cam.ac.uk
Date Deposited: 08 Apr 2020 20:56
Last Modified: 09 Sep 2021 02:13
DOI: 10.1039/c9lc01192g