CUED Publications database

Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion.

Koo, J and Kim, SB and Choi, YS and Xie, Z and Bandodkar, AJ and Khalifeh, J and Yan, Y and Kim, H and Pezhouh, MK and Doty, K and Lee, G and Chen, Y-Y and Lee, SM and D'Andrea, D and Jung, K and Lee, K and Li, K and Jo, S and Wang, H and Kim, J-H and Kim, J and Choi, S-G and Jang, WJ and Oh, YS and Park, I and Kwak, SS and Park, J-H and Hong, D and Feng, X and Lee, C-H and Banks, A and Leal, C and Lee, HM and Huang, Y and Franz, CK and Ray, WZ and MacEwan, M and Kang, S-K and Rogers, JA (2020) Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion. Sci Adv, 6. eabb1093-.

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Abstract

Implantable drug release platforms that offer wirelessly programmable control over pharmacokinetics have potential in advanced treatment protocols for hormone imbalances, malignant cancers, diabetic conditions, and others. We present a system with this type of functionality in which the constituent materials undergo complete bioresorption to eliminate device load from the patient after completing the final stage of the release process. Here, bioresorbable polyanhydride reservoirs store drugs in defined reservoirs without leakage until wirelessly triggered valve structures open to allow release. These valves operate through an electrochemical mechanism of geometrically accelerated corrosion induced by passage of electrical current from a wireless, bioresorbable power-harvesting unit. Evaluations in cell cultures demonstrate the efficacy of this technology for the treatment of cancerous tissues by release of the drug doxorubicin. Complete in vivo studies of platforms with multiple, independently controlled release events in live-animal models illustrate capabilities for control of blood glucose levels by timed delivery of insulin.

Item Type: Article
Subjects: UNSPECIFIED
Divisions: Div C > Materials Engineering
Depositing User: Cron Job
Date Deposited: 09 Sep 2020 21:06
Last Modified: 24 Nov 2020 08:15
DOI: 10.1126/sciadv.abb1093