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Dendritic trafficking: synaptic scaling and structural plasticity

Aljaberi, S and O'Leary, T and Forni, F Dendritic trafficking: synaptic scaling and structural plasticity. (Unpublished)

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Abstract

Neuronal circuits internally regulate electrical signaling via a host of homeostatic mechanisms. Two prominent mechanisms, synaptic scaling and structural plasticity, are believed to maintain average activity within an operating range by modifying the strength and spatial extent of network connectivity using negative feedback. However, both mechanisms operate on relatively slow timescales and thus face fundamental limits due to delays. We show that these mechanisms fulfill complementary roles in maintaining stability in a large network. In particular, even relatively, slow growth dynamics improves performance significantly beyond synaptic scaling alone.

Item Type: Article
Uncontrolled Keywords: q-bio.NC q-bio.NC cs.SY eess.SY
Subjects: UNSPECIFIED
Divisions: Div F > Control
Depositing User: Cron Job
Date Deposited: 04 Dec 2020 22:36
Last Modified: 15 Apr 2021 05:28
DOI: