CUED Publications database

Guided Assembly and Patterning of Intrinsically Fluorescent Amyloid Fibers with Long-Range Order

Hecker, L and Wang, W and Mela, I and Fathi, S and Poudel, C and Soavi, G and Huang, YYS and Kaminski, CF (2021) Guided Assembly and Patterning of Intrinsically Fluorescent Amyloid Fibers with Long-Range Order. Nano Letters, 21. pp. 938-945. ISSN 1530-6984

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Abstract

Fibrillar amyloids exhibit a fascinating range of mechanical, optical, and electronic properties originating from their characteristic β-sheet-rich structure. Harnessing these functionalities in practical applications has so far been hampered by a limited ability to control the amyloid self-assembly process at the macroscopic scale. Here, we use core-shell electrospinning with microconfinement to assemble amyloid-hybrid fibers, consisting of densely aggregated fibrillar amyloids stabilized by a polymer shell. Up to centimeter-long hybrid fibers with micrometer diameter can be arranged into aligned and ordered arrays and deposited onto substrates or produced as free-standing networks. Properties that are characteristic of amyloids, including their high elastic moduli and intrinsic fluorescence signature, are retained in the hybrid fiber cores, and we show that they fully persist through the macroscopic fiber patterns. Our findings suggest that microlevel confinement is key for the guided assembly of amyloids from monomeric proteins.

Item Type: Article
Uncontrolled Keywords: direct writing electrospinning functional amyloid materials guided protein self-assembly intrinsic fluorescence protein fibers
Subjects: UNSPECIFIED
Divisions: Div C > Biomechanics
Depositing User: Cron Job
Date Deposited: 20 Jan 2021 20:09
Last Modified: 13 Apr 2021 09:07
DOI: 10.1021/acs.nanolett.0c03672