CUED Publications database

Pilot study of a non-invasive real-time optical backscatter probe in liver transplantation.

Richards, JA and Randle, LV and Butler, AJ and Martin, JL and Fedotovs, A and Davies, SE and Watson, CJE and Robertson, PA (2021) Pilot study of a non-invasive real-time optical backscatter probe in liver transplantation. Transplant International. ISSN 0934-0874 (Unpublished)

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Abstract

Transplantation of severely steatotic donor livers is associated with early allograft dysfunction and poorer graft survival. Histology remains the gold standard diagnostic of donor steatosis despite the lack of consensus definition and its subjective nature. In this prospective observational study of liver transplant patients, we demonstrate the feasibility of using a handheld optical backscatter probe to assess the degree of hepatic steatosis and correlate the backscatter readings with clinical outcomes. The probe is placed on the surface of the liver and emits red and near infrared light from the tip of the device and measures the amount of backscatter of light from liver tissue via two photodiodes. Measurement of optical backscatter (Mantel Cox p<0.0001) and histopathological scoring of macrovesicular steatosis (Mantel Cox p=0.046), were predictive of 5-year graft survival. Recipients with early allograft dysfunction defined according to both Olthoff (p=0.0067) and MEAF score (p=0.0097) had significantly higher backscatter levels from the donor organ. Backscatter was predictive of graft loss (AUC 0.75, p=0.0045). This study demonstrates the feasibility of real-time measurement of optical backscatter in donor livers. Early results indicate readings correlate with steatosis and may give insight to graft outcomes such as early allograft dysfunction and graft loss.

Item Type: Article
Uncontrolled Keywords: Deceased Donation Fatty Liver Disease Hepatic Steatosis Liver Transplantation Outcomes Medical Device
Subjects: UNSPECIFIED
Divisions: UNSPECIFIED
Depositing User: Cron Job
Date Deposited: 20 Jan 2021 20:09
Last Modified: 13 Apr 2021 10:08
DOI: 10.1111/tri.13823