CUED Publications database

Cadmium-induced dysfunction of the blood-brain barrier depends on ROS-mediated inhibition of PTPase activity in zebrafish

Zhang, T and Xu, Z and Wen, L and Lei, D and Li, S and Wang, J and Huang, J and Wang, N and Durkan, C and Liao, X and Wang, G (2021) Cadmium-induced dysfunction of the blood-brain barrier depends on ROS-mediated inhibition of PTPase activity in zebrafish. Journal of Hazardous Materials, 412. 125198-. ISSN 0304-3894

Full text not available from this repository.

Abstract

Increasing evidence has demonstrated that cadmium accumulation in the blood increases the risk of neurological diseases. However, how cadmium breaks through the blood-brain barrier (BBB) and is transferred from the blood circulation into the central nervous system is still unclear. In this study, we examined the toxic effect of cadmium chloride (CdCl ) on the development and function of BBB in zebrafish. CdCl exposure induced cerebral hemorrhage, increased BBB permeability and promoted abnormal vascular formation by promoting VEGF production in zebrafish brain. Furthermore, in vivo and in vitro experiments showed that CdCl altered cell-cell junctional morphology by disrupting the proper localization of VE-cadherin and ZO-1. The potential mechanism involved in the inhibition of protein tyrosine phosphatase (PTPase) mediated by cadmium-induced ROS was confirmed with diphenylene iodonium (DPI), a ROS production inhibitor. Together, these data indicate that BBB is a critical target of cadmium toxicity and provide in vivo etiological evidence of cadmium-induced neurovascular disease in a zebrafish BBB model. 2 2 2

Item Type: Article
Uncontrolled Keywords: BBB CdCl(2) Cerebral hemorrhage Junctional disruption Reactive oxygen
Subjects: UNSPECIFIED
Divisions: UNSPECIFIED
Depositing User: Cron Job
Date Deposited: 10 Feb 2021 21:05
Last Modified: 13 Apr 2021 10:01
DOI: 10.1016/j.jhazmat.2021.125198