CUED Publications database

Dynamical SPQEIR model assesses the effectiveness of non-pharmaceutical interventions against COVID-19 epidemic outbreaks.

Proverbio, D and Kemp, F and Magni, S and Husch, A and Aalto, A and Mombaerts, L and Skupin, A and Gonçalves, J and Ameijeiras-Alonso, J and Ley, C (2021) Dynamical SPQEIR model assesses the effectiveness of non-pharmaceutical interventions against COVID-19 epidemic outbreaks. PLoS One, 16. e0252019-.

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Abstract

Against the current COVID-19 pandemic, governments worldwide have devised a variety of non-pharmaceutical interventions to mitigate it. However, it is generally difficult to estimate the joint impact of different control strategies. In this paper, we tackle this question with an extended epidemic SEIR model, informed by a socio-political classification of different interventions. First, we inquire the conceptual effect of mitigation parameters on the infection curve. Then, we illustrate the potential of our model to reproduce and explain empirical data from a number of countries, to perform cross-country comparisons. This gives information on the best synergies of interventions to control epidemic outbreaks while minimising impact on socio-economic needs. For instance, our results suggest that, while rapid and strong lockdown is an effective pandemic mitigation measure, a combination of social distancing and early contact tracing can achieve similar mitigation synergistically, while keeping lower isolation rates. This quantitative understanding can support the establishment of mid- and long-term interventions, to prepare containment strategies against further outbreaks. This paper also provides an online tool that allows researchers and decision makers to interactively simulate diverse scenarios with our model.

Item Type: Article
Uncontrolled Keywords: COVID-19 Contact Tracing Humans Models, Statistical Physical Distancing Quarantine
Subjects: UNSPECIFIED
Divisions: Div F > Control
Depositing User: Unnamed user with email sms67@cam.ac.uk
Date Deposited: 23 May 2021 20:24
Last Modified: 09 Sep 2021 02:03
DOI: 10.1371/journal.pone.0252019