CUED Publications database

Electrical and optical spectroscopy for quantitative screening of hepatic steatosis in donor livers.

McLaughlin, BL and Wells, AC and Virtue, S and Vidal-Puig, A and Wilkinson, TD and Watson, CJ and Robertson, PA (2010) Electrical and optical spectroscopy for quantitative screening of hepatic steatosis in donor livers. Phys Med Biol, 55. pp. 6867-6879.

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Abstract

Macro-steatosis in deceased donor livers is increasingly prevalent and is associated with poor or non-function of the liver upon reperfusion. Current assessment of the extent of steatosis depends upon the macroscopic assessment of the liver by the surgeon and histological examination, if available. In this paper we demonstrate electrical and optical spectroscopy techniques which quantitatively characterize fatty infiltration in liver tissue. Optical spectroscopy showed a correlation coefficient of 0.85 in humans when referenced to clinical hematoxylin and eosin (H&E) sections in 20 human samples. With further development, an optical probe may provide a comprehensive measure of steatosis across the liver at the time of procurement.

Item Type: Article
Uncontrolled Keywords: Animals Dielectric Spectroscopy Fatty Liver Female Humans Liver Mice Optical Fibers Optical Processes Point-of-Care Systems Spectrophotometry, Infrared Time Factors Tissue Donors
Subjects: UNSPECIFIED
Divisions: Div B > Photonics
Depositing User: Cron Job
Date Deposited: 07 Mar 2014 11:22
Last Modified: 26 Nov 2014 19:06
DOI: 10.1088/0031-9155/55/22/017