CUED Publications database

Integration of holographic sensors into microfluidics for the real-time pH sensing of L. casei metabolism

Bell, LL and Seshia, AA and Davidson, CAB and Lowe, CR (2010) Integration of holographic sensors into microfluidics for the real-time pH sensing of L. casei metabolism. Procedia Engineering, 5. pp. 1352-1355. ISSN 1877-7058

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Abstract

We describe developments in the integration of analyte specific holographic sensors into PDMS-based microfluidic devices for the purpose of continuous, low-impact monitoring of extra-cellular change in micro-bioreactors. Holographic sensors respond to analyte concentration via volume change, which makes their reduction in size and integration into spatially confined fluidics difficult. Through design and process modification many of these constraints have been addressed, and a microfluidics-based device capable of real-time monitoring of the pH change caused by Lactobacillus casei fermentation is presented as a general proof-of-concept for a wide array of possible devices.

Item Type: Article
Uncontrolled Keywords: Biosensor Holography Microfluidics PDMS pH sensor
Subjects: UNSPECIFIED
Divisions: Div C > Applied Mechanics
Depositing User: Cron Job
Date Deposited: 07 Mar 2014 11:40
Last Modified: 08 Dec 2014 02:37
DOI: 10.1016/j.proeng.2010.09.365