CUED Publications database

Characterisation of cell adhesion to substrate materials and the resistance to enzymatic and mechanical cell-removal

Griffiths, HJ and Harvey, JG and Dean, J and Curran, JA and Markaki, AE and Clyne, TW (2008) Characterisation of cell adhesion to substrate materials and the resistance to enzymatic and mechanical cell-removal. Materials Research Society Symposium Proceedings, 1097. pp. 45-50. ISSN 0272-9172

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Abstract

Cell-implant adhesive strength is important for prostheses. In this paper, an investigation is described into the adhesion of bovine chondrocytes to Ti6Al4V-based substrates with different surface roughnesses and compositions. Cells were cultured for 2 or 5 days, to promote adhesion. The ease of cell removal was characterised, using both biochemical (trypsin) and mechanical (accelerated buoyancy and liquid flow) methods. Computational fluid dynamics (CFD) modelling has been used to estimate the shear forces applied to the cells by the liquid flow. A comparison is presented between the ease of cell detachment indicated using these methods, for the three surfaces investigated. © 2008 Materials Research Society.

Item Type: Article
Subjects: UNSPECIFIED
Divisions: Div C > Materials Engineering
Div C > Biomechanics
Depositing User: Cron Job
Date Deposited: 07 Mar 2014 12:06
Last Modified: 28 Nov 2014 19:06
DOI: