CUED Publications database

Geometric optimization methods for the analysis of gene expression data

Journée, M and Teschendorff, AE and Absil, P-A and Tavaré, S and Sepulchre, R (2008) Geometric optimization methods for the analysis of gene expression data. In: UNSPECIFIED UNSPECIFIED, pp. 271-292.

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Abstract

DNA microarrays provide such a huge amount of data that unsupervised methods are required to reduce the dimension of the data set and to extract meaningful biological information. This work shows that Independent Component Analysis (ICA) is a promising approach for the analysis of genome-wide transcriptomic data. The paper first presents an overview of the most popular algorithms to perform ICA. These algorithms are then applied on a microarray breast-cancer data set. Some issues about the application of ICA and the evaluation of biological relevance of the results are discussed. This study indicates that ICA significantly outperforms Principal Component Analysis (PCA).

Item Type: Book Section
Subjects: UNSPECIFIED
Divisions: Div F > Control
Depositing User: Cron job
Date Deposited: 04 Feb 2015 23:03
Last Modified: 05 Feb 2015 08:21
DOI: 10.1007/978-3-540-73750-6_12