CUED Publications database

Fabrication and bio-functionalization of tetrahedral amorphous carbon thin films for bio sensor applications

Yu, H and Li, P and Robertson, J (2011) Fabrication and bio-functionalization of tetrahedral amorphous carbon thin films for bio sensor applications. Diamond and Related Materials, 20. pp. 1020-1025. ISSN 0925-9635

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Abstract

Tetrahedral amorphous carbon (ta-C) thin films are a promising material for use as biocompatible interfaces in applications such as in-vivo biosensors. However, the functionalization of ta-C film surface, which is a pre-requisite for biosensors, remains a big challenge due to its chemical inertness. We have investigated the bio-functionalization of ta-C films fabricated under specific physical conditions through the covalent attachment of functional biomolecular probes of peptide nucleic acid (PNA) to ta-C films, and the effect of fabrication conditions on the bio-functionalization. The study showed that the functional bimolecular probes such as protected long-chain ω-unsaturated amine (TFAAD) can be covalently attached to the ta-C surface through a well-defined structure. With the given fabrication process, electrochemical methods can be applied to the detection of biomolecular interaction, which establishes the basis for the development of stable, label-free biosensors. © 2011 Elsevier B.V. All rights reserved.

Item Type: Article
Uncontrolled Keywords: bio-functionalization Biosensor diamond-like carbon electrochemical
Subjects: UNSPECIFIED
Divisions: Div B > Solid State Electronics and Nanoscale Science
Depositing User: Cron Job
Date Deposited: 07 Mar 2014 11:43
Last Modified: 09 Dec 2014 09:45
DOI: 10.1016/j.diamond.2011.06.005