CUED Publications database

An extended computational model of the circulatory system for designing ventricular assist devices.

Hsu, PL and Cheng, SJ and Saumarez, RC and Dawes, WN and McMahon, RA (2008) An extended computational model of the circulatory system for designing ventricular assist devices. ASAIO J, 54. pp. 594-599.

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An extended computational model of the circulatory system has been developed to predict blood flow in the presence of ventricular assist devices (VADs). A novel VAD, placed in the descending aorta, intended to offload the left ventricle (LV) and augment renal perfusion is being studied. For this application, a better understanding of the global hemodynamic response of the VAD, in essence an electrically driven pump, and the cardiovascular system is necessary. To meet this need, a model has been established as a nonlinear, lumped-parameter electrical analog, and simulated results under different states [healthy, congestive heart failure (CHF), and postinsertion of VAD] are presented. The systemic circulation is separated into five compartments and the descending aorta is composed of three components to accurately yield the system response of each section before and after the insertion of the VAD. Delays in valve closing time and blood inertia in the aorta were introduced to deliver a more realistic model. Pump governing equations and optimization are based on fundamental theories of turbomachines and can serve as a practical initial design point for rotary blood pumps. The model's results closely mimic established parameters for the circulatory system and confirm the feasibility of the intra-aortic VAD concept. This computational model can be linked with models of the pump motor to provide a valuable tool for innovative VAD design.

Item Type: Article
Uncontrolled Keywords: Algorithms Cardiovascular Physiological Processes Heart-Assist Devices Hemodynamics Models, Cardiovascular Prosthesis Design
Divisions: Div A > Turbomachinery
Div B > Electronics, Power & Energy Conversion
Depositing User: Unnamed user with email
Date Deposited: 18 May 2016 17:57
Last Modified: 28 Jul 2016 04:42
DOI: 10.1097/MAT.0b013e318185e1ce