CUED Publications database

Material model of lung parenchyma based on living precision-cut lung slice testing.

Rausch, SMK and Martin, C and Bornemann, PB and Uhlig, S and Wall, WA (2011) Material model of lung parenchyma based on living precision-cut lung slice testing. J Mech Behav Biomed Mater, 4. pp. 583-592.

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We describe a novel constitutive model of lung parenchyma, which can be used for continuum mechanics based predictive simulations. To develop this model, we experimentally determined the nonlinear material behavior of rat lung parenchyma. This was achieved via uni-axial tension tests on living precision-cut rat lung slices. The resulting force-displacement curves were then used as inputs for an inverse analysis. The Levenberg-Marquardt algorithm was utilized to optimize the material parameters of combinations and recombinations of established strain-energy density functions (SEFs). Comparing the best-fits of the tested SEFs we found Wpar = 4.1 kPa(I1-3)2 + 20.7 kPa(I1 - 3)3 + 4.1 kPa(-2 ln J + J2 - 1) to be the optimal constitutive model. This SEF consists of three summands: the first can be interpreted as the contribution of the elastin fibers and the ground substance, the second as the contribution of the collagen fibers while the third controls the volumetric change. The presented approach will help to model the behavior of the pulmonary parenchyma and to quantify the strains and stresses during ventilation.

Item Type: Article
Uncontrolled Keywords: Animals Female Lung Materials Testing Models, Biological Rats Rats, Wistar Stress, Mechanical
Divisions: Div D > Structures
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:25
Last Modified: 24 May 2018 02:08