CUED Publications database

On the growth and form of the gut.

Savin, T and Kurpios, NA and Shyer, AE and Florescu, P and Liang, H and Mahadevan, L and Tabin, CJ (2011) On the growth and form of the gut. Nature, 476. pp. 57-62.

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The developing vertebrate gut tube forms a reproducible looped pattern as it grows into the body cavity. Here we use developmental experiments to eliminate alternative models and show that gut looping morphogenesis is driven by the homogeneous and isotropic forces that arise from the relative growth between the gut tube and the anchoring dorsal mesenteric sheet, tissues that grow at different rates. A simple physical mimic, using a differentially strained composite of a pliable rubber tube and a soft latex sheet is consistent with this mechanism and produces similar patterns. We devise a mathematical theory and a computational model for the number, size and shape of intestinal loops based solely on the measurable geometry, elasticity and relative growth of the tissues. The predictions of our theory are quantitatively consistent with observations of intestinal loops at different stages of development in the chick embryo. Our model also accounts for the qualitative and quantitative variation in the distinct gut looping patterns seen in a variety of species including quail, finch and mouse, illuminating how the simple macroscopic mechanics of differential growth drives the morphology of the developing gut.

Item Type: Article
Uncontrolled Keywords: Animals Biomechanical Phenomena Chick Embryo Computer Simulation Elasticity Female Finches Intestines Mesentery Mice Models, Anatomic Models, Biological Quail Rotation Rubber
Divisions: Div C > Biomechanics
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 18:58
Last Modified: 21 Jun 2018 02:39