CUED Publications database

Probing small molecule binding to amyloid fibrils.

Buell, AK and Esbjörner, EK and Riss, PJ and White, DA and Aigbirhio, FI and Toth, G and Welland, ME and Dobson, CM and Knowles, TP (2011) Probing small molecule binding to amyloid fibrils. Phys Chem Chem Phys, 13. pp. 20044-20052.

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Abstract

Much effort has focussed in recent years on probing the interactions of small molecules with amyloid fibrils and other protein aggregates. Understanding and control of such interactions are important for the development of diagnostic and therapeutic strategies in situations where protein aggregation is associated with disease. In this perspective article we give an overview over the toolbox of biophysical methods for the study of such amyloid-small molecule interactions. We discuss in detail two recently developed techniques within this framework: linear dichroism, a promising extension of the more traditional spectroscopic techniques, and biosensing methods, where surface-bound amyloid fibrils are exposed to solutions of small molecules. Both techniques rely on the measurement of physical properties that are very directly linked to the binding of small molecules to amyloid aggregates and therefore provide an attractive route to probe these important interactions.

Item Type: Article
Uncontrolled Keywords: Alzheimer Disease Amyloid Animals Humans Protein Binding Quartz Crystal Microbalance Techniques Small Molecule Libraries Spectrum Analysis
Subjects: UNSPECIFIED
Divisions: Div B > Solid State Electronics and Nanoscale Science
Depositing User: Cron Job
Date Deposited: 07 Mar 2014 11:20
Last Modified: 19 Sep 2014 19:02
DOI: 10.1039/c1cp22283j

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