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Cell adhesion to plasma electrolytic oxidation (PEO) titania coatings, assessed using a centrifuging technique.

Robinson, HJ and Markaki, AE and Collier, CA and Clyne, TW (2011) Cell adhesion to plasma electrolytic oxidation (PEO) titania coatings, assessed using a centrifuging technique. J Mech Behav Biomed Mater, 4. pp. 2103-2112.

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Abstract

The adhesion of bovine chondrocytes and human osteoblasts to three titania-based coatings, formed by plasma electrolytic oxidation (PEO), was compared to that on uncoated Ti-6Al-4V substrates, and some comparisons were also made with plasma sprayed hydroxyapatite (HA) coatings. This was done using a centrifuge, with accelerations of up to 160,000 g, so as to induce buoyancy forces that created normal or shear stresses at the interface. It is shown that, on all surfaces, it was easier to remove cells under normal loading than under shear loading. Cell adhesion to the PEO coatings was stronger than that on Ti-6Al-4V and similar to that on HA. Cell proliferation rates were relatively high on one of the PEO coatings, which was virtually free of aluminium, but low on the other two, which contained significant levels of aluminium. It is concluded that the Al-free PEO coating offers promise for application to prosthetic implants.

Item Type: Article
Uncontrolled Keywords: Animals Cattle Cell Adhesion Cell Proliferation Centrifugation Chondrocytes Electrolysis Humans Osteoblasts Oxidation-Reduction Plasma Gases Stress, Mechanical Surface Properties Titanium
Subjects: UNSPECIFIED
Divisions: Div C > Materials Engineering
Div C > Biomechanics
Depositing User: Cron Job
Date Deposited: 07 Mar 2014 11:30
Last Modified: 26 Mar 2014 19:15
DOI: 10.1016/j.jmbbm.2011.07.009

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