Treece, GM and Poole, KE and Gee, AH (2012) Imaging the femoral cortex: thickness, density and mass from clinical CT. Med Image Anal, 16. pp. 952-965.Full text not available from this repository.
There is growing evidence that focal thinning of cortical bone in the proximal femur may predispose a hip to fracture. Detecting such defects in clinical CT is challenging, since cortices may be significantly thinner than the imaging system's point spread function. We recently proposed a model-fitting technique to measure sub-millimetre cortices, an ill-posed problem which was regularized by assuming a specific, fixed value for the cortical density. In this paper, we develop the work further by proposing and evaluating a more rigorous method for estimating the constant cortical density, and extend the paradigm to encompass the mapping of cortical mass (mineral mg/cm(2)) in addition to thickness. Density, thickness and mass estimates are evaluated on sixteen cadaveric femurs, with high resolution measurements from a micro-CT scanner providing the gold standard. The results demonstrate robust, accurate measurement of peak cortical density and cortical mass. Cortical thickness errors are confined to regions of thin cortex and are bounded by the extent to which the local density deviates from the peak, averaging 20% for 0.5mm cortex.
|Additional Information:||PMCID: PMC3417239|
|Uncontrolled Keywords:||Absorptiometry, Photon Algorithms Bone Density Femur Humans Imaging, Three-Dimensional Organ Size Radiographic Image Interpretation, Computer-Assisted Reference Values Reproducibility of Results Sensitivity and Specificity Tomography, X-Ray Computed|
|Divisions:||Div F > Machine Intelligence|
|Depositing User:||Cron Job|
|Date Deposited:||08 Apr 2012 19:02|
|Last Modified:||20 May 2013 01:36|
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