Vanleene, M and Porter, A and Guillot, PV and Boyde, A and Oyen, M and Shefelbine, S (2012) Ultra-structural defects cause low bone matrix stiffness despite high mineralization in osteogenesis imperfecta mice. Bone, 50. pp. 1317-1323.Full text not available from this repository.
Bone is a complex material with a hierarchical multi-scale organization from the molecule to the organ scale. The genetic bone disease, osteogenesis imperfecta, is primarily caused by mutations in the collagen type I genes, resulting in bone fragility. Because the basis of the disease is molecular with ramifications at the whole bone level, it provides a platform for investigating the relationship between structure, composition, and mechanics throughout the hierarchy. Prior studies have individually shown that OI leads to: 1. increased bone mineralization, 2. decreased elastic modulus, and 3. smaller apatite crystal size. However, these have not been studied together and the mechanism for how mineral structure influences tissue mechanics has not been identified. This lack of understanding inhibits the development of more accurate models and therapies. To address this research gap, we used a mouse model of the disease (oim) to measure these outcomes together in order to propose an underlying mechanism for the changes in properties. Our main finding was that despite increased mineralization, oim bones have lower stiffness that may result from the poorly organized mineral matrix with significantly smaller, highly packed and disoriented apatite crystals. Using a composite framework, we interpret the lower oim bone matrix elasticity observed as the result of a change in the aspect ratio of apatite crystals and a disruption of the crystal connectivity.
|Uncontrolled Keywords:||Animals Apatites Biomechanical Phenomena Bone Density Bone Matrix Crystallization Disease Models, Animal Elastic Modulus Female Male Mice Mice, Mutant Strains Microscopy, Electron, Scanning Microscopy, Electron, Transmission Osteogenesis Imperfecta Stress, Mechanical|
|Depositing User:||Cron job|
|Date Deposited:||04 Feb 2015 22:45|
|Last Modified:||24 May 2015 10:58|