Buell, AK and Dhulesia, A and White, DA and Knowles, TP and Dobson, CM and Welland, ME (2012) Detailed analysis of the energy barriers for amyloid fibril growth. Angew Chem Int Ed Engl, 51. pp. 5247-5251.Full text not available from this repository.
The free energy barriers that determine the kinetics of the growth of amyloid fibrils have been measured for a series of peptides and proteins using a quartz crystal microbalance. The results indicate that the enthalpic contribution to the free energy barrier is invariably unfavorable and correlates with the size and structure of the soluble parent polypeptide, whereas the entropic contribution is favorable and linked to the hydrophobicity of the peptide sequence.
|Uncontrolled Keywords:||Amyloid Kinetics Microscopy, Atomic Force Solubility|
|Depositing User:||Cron Job|
|Date Deposited:||28 Apr 2012 11:10|
|Last Modified:||09 Dec 2013 01:11|
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