CUED Publications database

Protein functionalized ZnO thin film bulk acoustic resonator as an odorant biosensor

Zhao, X and Ashley, GM and Garcia-Gancedo, L and Jin, H and Luo, J and Flewitt, AJ and Lu, JR (2012) Protein functionalized ZnO thin film bulk acoustic resonator as an odorant biosensor. Sensors and Actuators, B: Chemical, 163. pp. 242-246. ISSN 0925-4005

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ZnO thin film bulk acoustic resonators (FBARs) with resonant frequency of ∼1.5 GHz have been fabricated to function as an odorant biosensor. Physical adsorption of an odorant binding protein (AaegOBP22 from Aedes aegypti) resulted in frequency down shift. N,N-diethyl-meta-toluamide (DEET) has been selected as a ligand to the odorant binding protein (OBP). Alternate exposure of the bare FBARs to nitrogen flow with and without DEET vapor did not cause any noticeable frequency change. However, frequency drop was detected when exposing the OBP loaded FBAR sensors to the nitrogen flow containing DEET vapor against nitrogen flow alone (control) and the extent of frequency shift was proportional to the amount of the protein immobilized on the FBAR surface, indicating a linear response to DEET binding. These findings demonstrate the potential of binding protein functionalized FBARs as odorant biosensors. © 2012 Elsevier B.V. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Biosensor DEET FBAR Gas sensor Odorant binding protein
Depositing User: Unnamed user with email
Date Deposited: 16 Jul 2015 13:20
Last Modified: 30 Nov 2015 14:21
DOI: 10.1016/j.snb.2012.01.046