CUED Publications database

Twisting transition between crystalline and fibrillar phases of aggregated peptides

Knowles, TPJ and De Simone, A and Fitzpatrick, AW and Baldwin, A and Meehan, S and Rajah, L and Vendruscolo, M and Welland, ME and Dobson, CM and Terentjev, EM (2012) Twisting transition between crystalline and fibrillar phases of aggregated peptides. Physical Review Letters, 109. ISSN 0031-9007

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Abstract

We study two distinctly ordered condensed phases of polypeptide molecules, amyloid fibrils and amyloidlike microcrystals, and the first-order twisting phase transition between these two states. We derive a single free-energy form which connects both phases. Our model identifies relevant degrees of freedom for describing the collective behavior of supramolecular polypeptide structures, reproduces accurately the results from molecular dynamics simulations as well as from experiments, and sheds light on the uniform nature of the dimensions of different peptide fibrils. © 2012 American Physical Society.

Item Type: Article
Subjects: UNSPECIFIED
Divisions: Div B > Solid State Electronics and Nanoscale Science
Depositing User: Cron Job
Date Deposited: 07 Mar 2014 11:22
Last Modified: 14 Dec 2014 12:45
DOI: 10.1103/PhysRevLett.109.158101