CUED Publications database

Correct biological timing in Arabidopsis requires multiple light-signaling pathways.

Dalchau, N and Hubbard, KE and Robertson, FC and Hotta, CT and Briggs, HM and Stan, G-B and Gonçalves, JM and Webb, AAR (2010) Correct biological timing in Arabidopsis requires multiple light-signaling pathways. Proc Natl Acad Sci U S A, 107. pp. 13171-13176.

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Circadian oscillators provide rhythmic temporal cues for a range of biological processes in plants and animals, enabling anticipation of the day/night cycle and enhancing fitness-associated traits. We have used engineering models to understand the control principles of a plant's response to seasonal variation. We show that the seasonal changes in the timing of circadian outputs require light regulation via feed-forward loops, combining rapid light-signaling pathways with entrained circadian oscillators. Linear time-invariant models of circadian rhythms were computed for 3,503 circadian-regulated genes and for the concentration of cytosolic-free calcium to quantify the magnitude and timing of regulation by circadian oscillators and light-signaling pathways. Bioinformatic and experimental analysis show that rapid light-induced regulation of circadian outputs is associated with seasonal rephasing of the output rhythm. We identify that external coincidence is required for rephasing of multiple output rhythms, and is therefore important in general phase control in addition to specific photoperiod-dependent processes such as flowering and hypocotyl elongation. Our findings uncover a fundamental design principle of circadian regulation, and identify the importance of rapid light-signaling pathways in temporal control.

Item Type: Article
Uncontrolled Keywords: Arabidopsis Arabidopsis Proteins Circadian Rhythm Gene Expression Regulation, Plant Light Light Signal Transduction Light-Harvesting Protein Complexes Models, Biological RNA, Messenger Reproducibility of Results
Divisions: Div F > Control
Depositing User: Unnamed user with email
Date Deposited: 17 Jul 2017 19:07
Last Modified: 09 Sep 2021 02:21
DOI: 10.1073/pnas.1001429107