Yoshida, W and Seymour, B and Koltzenburg, M and Dolan, RJ (2013) Uncertainty increases pain: evidence for a novel mechanism of pain modulation involving the periaqueductal gray. J Neurosci, 33. pp. 5638-5646.Full text not available from this repository.
Predictions about sensory input exert a dominant effect on what we perceive, and this is particularly true for the experience of pain. However, it remains unclear what component of prediction, from an information-theoretic perspective, controls this effect. We used a vicarious pain observation paradigm to study how the underlying statistics of predictive information modulate experience. Subjects observed judgments that a group of people made to a painful thermal stimulus, before receiving the same stimulus themselves. We show that the mean observed rating exerted a strong assimilative effect on subjective pain. In addition, we show that observed uncertainty had a specific and potent hyperalgesic effect. Using computational functional magnetic resonance imaging, we found that this effect correlated with activity in the periaqueductal gray. Our results provide evidence for a novel form of cognitive hyperalgesia relating to perceptual uncertainty, induced here by vicarious observation, with control mediated by the brainstem pain modulatory system.
|Additional Information:||PMCID: PMC3701089|
|Uncontrolled Keywords:||Brain Mapping Computer Simulation Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Models, Biological Oxygen Pain Pain Measurement Pain Perception Pain Threshold Periaqueductal Gray Physical Stimulation Uncertainty|
|Divisions:||Div F > Computational and Biological Learning|
|Depositing User:||Cron Job|
|Date Deposited:||28 Apr 2013 05:10|
|Last Modified:||04 Nov 2013 01:05|
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