Seymour, B and Daw, ND and Roiser, JP and Dayan, P and Dolan, R (2012) Serotonin selectively modulates reward value in human decision-making. J Neurosci, 32. pp. 5833-5842.Full text not available from this repository.
Establishing a function for the neuromodulator serotonin in human decision-making has proved remarkably difficult because if its complex role in reward and punishment processing. In a novel choice task where actions led concurrently and independently to the stochastic delivery of both money and pain, we studied the impact of decreased brain serotonin induced by acute dietary tryptophan depletion. Depletion selectively impaired both behavioral and neural representations of reward outcome value, and hence the effective exchange rate by which rewards and punishments were compared. This effect was computationally and anatomically distinct from a separate effect on increasing outcome-independent choice perseveration. Our results provide evidence for a surprising role for serotonin in reward processing, while illustrating its complex and multifarious effects.
|Uncontrolled Keywords:||Brain Brain Mapping Conditioning, Operant Decision Making Dietary Supplements Double-Blind Method Electric Stimulation Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Oxygen Pain Pain Measurement Probability Punishment Questionnaires Reward Serotonin Statistics as Topic Tryptophan|
|Divisions:||Div F > Computational and Biological Learning|
|Depositing User:||Cron job|
|Date Deposited:||04 Feb 2015 22:34|
|Last Modified:||02 Mar 2015 01:24|