CUED Publications database

Modulation of pain ratings by expectation and uncertainty: Behavioral characteristics and anticipatory neural correlates.

Brown, CA and Seymour, B and Boyle, Y and El-Deredy, W and Jones, AK (2008) Modulation of pain ratings by expectation and uncertainty: Behavioral characteristics and anticipatory neural correlates. Pain, 135. pp. 240-250.

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Abstract

Expectations about the magnitude of impending pain exert a substantial effect on subsequent perception. However, the neural mechanisms that underlie the predictive processes that modulate pain are poorly understood. In a combined behavioral and high-density electrophysiological study we measured anticipatory neural responses to heat stimuli to determine how predictions of pain intensity, and certainty about those predictions, modulate brain activity and subjective pain ratings. Prior to receiving randomized laser heat stimuli at different intensities (low, medium or high) subjects (n=15) viewed cues that either accurately informed them of forthcoming intensity (certain expectation) or not (uncertain expectation). Pain ratings were biased towards prior expectations of either high or low intensity. Anticipatory neural responses increased with expectations of painful vs. non-painful heat intensity, suggesting the presence of neural responses that represent predicted heat stimulus intensity. These anticipatory responses also correlated with the amplitude of the Laser-Evoked Potential (LEP) response to painful stimuli when the intensity was predictable. Source analysis (LORETA) revealed that uncertainty about expected heat intensity involves an anticipatory cortical network commonly associated with attention (left dorsolateral prefrontal, posterior cingulate and bilateral inferior parietal cortices). Relative certainty, however, involves cortical areas previously associated with semantic and prospective memory (left inferior frontal and inferior temporal cortex, and right anterior prefrontal cortex). This suggests that biasing of pain reports and LEPs by expectation involves temporally precise activity in specific cortical networks.

Item Type: Article
Uncontrolled Keywords: Adult Attention Behavior Brain Mapping Cerebral Cortex Cognition Cues Electroencephalography Evoked Potentials Functional Laterality Humans Lasers Memory Mental Processes Middle Aged Nerve Net Neuropsychological Tests Pain Pain Measurement Pain Threshold Physical Stimulation Uncertainty
Subjects: UNSPECIFIED
Divisions: Div F > Computational and Biological Learning
Depositing User: Cron Job
Date Deposited: 07 Mar 2014 11:21
Last Modified: 29 Sep 2014 01:01
DOI: 10.1016/j.pain.2007.05.022