Seymour, B and Daw, N and Dayan, P and Singer, T and Dolan, R (2007) Differential encoding of losses and gains in the human striatum. J Neurosci, 27. pp. 4826-4831.Full text not available from this repository.
Studies on human monetary prediction and decision making emphasize the role of the striatum in encoding prediction errors for financial reward. However, less is known about how the brain encodes financial loss. Using Pavlovian conditioning of visual cues to outcomes that simultaneously incorporate the chance of financial reward and loss, we show that striatal activation reflects positively signed prediction errors for both. Furthermore, we show functional segregation within the striatum, with more anterior regions showing relative selectivity for rewards and more posterior regions for losses. These findings mirror the anteroposterior valence-specific gradient reported in rodents and endorse the role of the striatum in aversive motivational learning about financial losses, illustrating functional and anatomical consistencies with primary aversive outcomes such as pain.
|Additional Information:||PMCID: PMC2630024|
|Uncontrolled Keywords:||Adult Brain Mapping Conditioning, Classical Corpus Striatum Female Humans Male Photic Stimulation Reward|
|Divisions:||Div F > Computational and Biological Learning|
|Depositing User:||Cron Job|
|Date Deposited:||28 Apr 2013 10:10|
|Last Modified:||13 Jan 2014 01:18|
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