Kalisch, R and Korenfeld, E and Stephan, KE and Weiskopf, N and Seymour, B and Dolan, RJ (2006) Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network. J Neurosci, 26. pp. 9503-9511.Full text not available from this repository.
In fear extinction, an animal learns that a conditioned stimulus (CS) no longer predicts a noxious stimulus [unconditioned stimulus (UCS)] to which it had previously been associated, leading to inhibition of the conditioned response (CR). Extinction creates a new CS-noUCS memory trace, competing with the initial fear (CS-UCS) memory. Recall of extinction memory and, hence, CR inhibition at later CS encounters is facilitated by contextual stimuli present during extinction training. In line with theoretical predictions derived from animal studies, we show that, after extinction, a CS-evoked engagement of human ventromedial prefrontal cortex (VMPFC) and hippocampus is context dependent, being expressed in an extinction, but not a conditioning, context. Likewise, a positive correlation between VMPFC and hippocampal activity is extinction context dependent. Thus, a VMPFC-hippocampal network provides for context-dependent recall of human extinction memory, consistent with a view that hippocampus confers context dependence on VMPFC.
|Additional Information:||PMCID: PMC2634865|
|Uncontrolled Keywords:||Adolescent Adult Avoidance Learning Brain Mapping Conditioning (Psychology) Electric Stimulation Extinction, Psychological Face Fear Female Hippocampus Humans Magnetic Resonance Imaging Male Memory Nerve Net Neural Pathways Prefrontal Cortex|
|Divisions:||Div F > Computational and Biological Learning|
|Depositing User:||Cron Job|
|Date Deposited:||28 Apr 2013 10:10|
|Last Modified:||02 Dec 2013 01:10|
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