CUED Publications database

Contingency awareness in human aversive conditioning involves the middle frontal gyrus.

Carter, RM and O'Doherty, JP and Seymour, B and Koch, C and Dolan, RJ (2005) Contingency awareness in human aversive conditioning involves the middle frontal gyrus. Neuroimage, 29. pp. 1007-1012. ISSN 1053-8119

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In contrast to the wealth of data describing the neural mechanisms underlying classical conditioning, we know remarkably little about the mechanisms involved in acquisition of explicit contingency awareness. Subjects variably acquire contingency awareness in classical conditioning paradigms, in which they are able to describe the temporal relationship between a conditioned cue and its outcome. Previous studies have implicated the hippocampus and prefrontal cortex in the acquisition of explicit knowledge, although their specific roles remain unclear. We used functional magnetic resonance imaging to track the trial-by-trial acquisition of explicit knowledge in a concurrent trace and delay conditioning paradigm. We show that activity in bilateral middle frontal gyrus and parahippocampal gyrus correlates with the accuracy of explicit contingency awareness on each trial. In contrast, amygdala activation correlates with conditioned responses indexed by skin conductance responses (SCRs). These results demonstrate that brain regions known to be involved in other aspects of learning and memory also play a specific role, reflecting on each trial the acquisition and representation of contingency awareness.

Item Type: Article
Uncontrolled Keywords: Adult Avoidance Learning Awareness Conditioning, Classical Female Frontal Lobe Galvanic Skin Response Hippocampus Humans Magnetic Resonance Imaging Male Memory, Short-Term Prefrontal Cortex Reinforcement, Psychology
Divisions: Div F > Computational and Biological Learning
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:20
Last Modified: 24 Nov 2020 09:44
DOI: 10.1016/j.neuroimage.2005.09.011