CUED Publications database

Predictive neural coding of reward preference involves dissociable responses in human ventral midbrain and ventral striatum.

O'Doherty, JP and Buchanan, TW and Seymour, B and Dolan, RJ (2006) Predictive neural coding of reward preference involves dissociable responses in human ventral midbrain and ventral striatum. Neuron, 49. pp. 157-166. ISSN 0896-6273

Full text not available from this repository.

Abstract

Food preferences are acquired through experience and can exert strong influence on choice behavior. In order to choose which food to consume, it is necessary to maintain a predictive representation of the subjective value of the associated food stimulus. Here, we explore the neural mechanisms by which such predictive representations are learned through classical conditioning. Human subjects were scanned using fMRI while learning associations between arbitrary visual stimuli and subsequent delivery of one of five different food flavors. Using a temporal difference algorithm to model learning, we found predictive responses in the ventral midbrain and a part of ventral striatum (ventral putamen) that were related directly to subjects' actual behavioral preferences. These brain structures demonstrated divergent response profiles, with the ventral midbrain showing a linear response profile with preference, and the ventral striatum a bivalent response. These results provide insight into the neural mechanisms underlying human preference behavior.

Item Type: Article
Uncontrolled Keywords: Adult Algorithms Cerebral Cortex Corpus Striatum Cues Female Food Preferences Humans Linear Models Magnetic Resonance Imaging Male Mesencephalon Models, Neurological Pupil Reaction Time Reward Taste
Subjects: UNSPECIFIED
Divisions: Div F > Computational and Biological Learning
Depositing User: Cron Job
Date Deposited: 07 Mar 2014 11:21
Last Modified: 28 Jul 2014 01:08
DOI: 10.1016/j.neuron.2005.11.014

Actions (login required)

View Item