CUED Publications database

Composite electrospun gelatin fiber-alginate gel scaffolds for mechanically robust tissue engineered cornea

Tonsomboon, K and Oyen, ML (2013) Composite electrospun gelatin fiber-alginate gel scaffolds for mechanically robust tissue engineered cornea. Journal of the Mechanical Behavior of Biomedical Materials, 21. pp. 185-194. ISSN 1751-6161

Full text not available from this repository.

Abstract

A severe shortage of good quality donor cornea is now an international crisis in public health. Alternatives for donor tissue need to be urgently developed to meet the increasing demand for corneal transplantation. Hydrogels have been widely used as scaffolds for corneal tissue regeneration due to their large water content, similar to that of native tissue. However, these hydrogel scaffolds lack the fibrous structure that functions as a load-bearing component in the native tissue, resulting in poor mechanical performance. This work shows that mechanical properties of compliant hydrogels can be substantially enhanced with electrospun nanofiber reinforcement. Electrospun gelatin nanofibers were infiltrated with alginate hydrogels, yielding transparent fiber-reinforced hydrogels. Without prior crosslinking, electrospun gelatin nanofibers improved the tensile elastic modulus of the hydrogels from 78±19. kPa to 450±100. kPa. Stiffer hydrogels, with elastic modulus of 820±210. kPa, were obtained by crosslinking the gelatin fibers with carbodiimide hydrochloride in ethanol before the infiltration process, but at the expense of transparency. The developed fiber-reinforced hydrogels show great promise as mechanically robust scaffolds for corneal tissue engineering applications. © 2013 Elsevier Ltd.

Item Type: Article
Uncontrolled Keywords: Corneal tissue engineering Electrospinning Gelatin fiber Hydrogel Scaffold
Subjects: UNSPECIFIED
Divisions: Div C > Biomechanics
Depositing User: Cron Job
Date Deposited: 07 Mar 2014 11:24
Last Modified: 08 Dec 2014 02:12
DOI: 10.1016/j.jmbbm.2013.03.001