CUED Publications database

Effects of functionalization on the targeting site of carbon nanotubes inside cells

Porter, AE and Bendall, JS and Gass, M and Muller, K and Skepper, J and Midgley, P and Welland, M (2010) Effects of functionalization on the targeting site of carbon nanotubes inside cells. In: UNSPECIFIED.

Full text not available from this repository.


Functionalized single-walled carbon nanotubes (SWNTs) are currently being investigated for a variety of applications, including contrast agents for medical imaging . However before they can be used commercially it is necessary to assess whether they enter cells, the site they target within the cell and whether they cause any cytotoxicity. Here we characterize uptake of unlabelled, acid-treated, COO functionalized SWNTs by human monocyte derived macrophage cells using both low-loss and energy loss spectroscopy and compare our findings to previous work on unpurified SWNTs. The acid-treated SWNTs were less aggregated within cells than unpurified SWNTs. Acid treatment was found to affect the distribution of intracellular SWNTs. Bundles, and also individual acid treated SWNTs, were found frequently inside lysosomes, cytoplasm and also inserting into the plasma membrane whereas unpurified non-functionalised SWNTs entered lysosomes and occasionally the nucleus. © 2010 IOP Publishing Ltd. 1 -

Item Type: Conference or Workshop Item (UNSPECIFIED)
Depositing User: Cron Job
Date Deposited: 13 Sep 2019 20:29
Last Modified: 10 Apr 2021 23:08
DOI: 10.1088/1742-6596/241/1/012018