CUED Publications database

Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo.

Pawlak, V and Greenberg, DS and Sprekeler, H and Gerstner, W and Kerr, JN (2013) Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo. Elife, 2. e00012-.

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Abstract

Action Potential (APs) patterns of sensory cortex neurons encode a variety of stimulus features, but how can a neuron change the feature to which it responds? Here, we show that in vivo a spike-timing-dependent plasticity (STDP) protocol-consisting of pairing a postsynaptic AP with visually driven presynaptic inputs-modifies a neurons' AP-response in a bidirectional way that depends on the relative AP-timing during pairing. Whereas postsynaptic APs repeatedly following presynaptic activation can convert subthreshold into suprathreshold responses, APs repeatedly preceding presynaptic activation reduce AP responses to visual stimulation. These changes were paralleled by restructuring of the neurons response to surround stimulus locations and membrane-potential time-course. Computational simulations could reproduce the observed subthreshold voltage changes only when presynaptic temporal jitter was included. Together this shows that STDP rules can modify output patterns of sensory neurons and the timing of single-APs plays a crucial role in sensory coding and plasticity.DOI:http://dx.doi.org/10.7554/eLife.00012.001.

Item Type: Article
Uncontrolled Keywords: STDP circuits in vivo rat spiking patterns synaptic plasticity visual cortex Action Potentials Animals Cerebral Cortex Mice Neurons Patch-Clamp Techniques
Subjects: UNSPECIFIED
Divisions: Div F > Computational and Biological Learning
Depositing User: Cron job
Date Deposited: 16 Jul 2015 13:32
Last Modified: 31 Aug 2015 04:23
DOI: 10.7554/eLife.00012