Bonjean, M and Phillips, C and Vu, TTD and Sepulchre, R and Maquet, P (2007) An in computo investigation of the Landau-Kleffner syndrome. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. pp. 2730-2734. ISSN 0589-1019Full text not available from this repository.
We describe a computational model of the thalamus and the cortex able to reproduce some essential epileptiform features commonly observed in the Landau-Kleffner syndrome. Investigation with this realistic model leads us to the formulation of a cellular mechanism that could be responsible for the epileptic discharges occuring with this severe syndrome. Understanding this mechanism is of prime importance for developing new therapeutical strategies. © 2007 IEEE.
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