CUED Publications database

Short-term cytotoxic and inflammatory responses of human monocytes to stainless steel fibre networks

Spear, RL and Brooks, RA and Markaki, AE (2012) Short-term cytotoxic and inflammatory responses of human monocytes to stainless steel fibre networks. Materials Research Society Symposium Proceedings, 1417. pp. 56-61. ISSN 0272-9172

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Abstract

The aim of the current work was to examine the human monocyte response to 444 ferritic stainless steel fibre networks. 316L austenitic fibre networks, of the same fibre volume fraction, were used as control surfaces. Fluorescence and scanning electron microscopies suggest that the cells exhibited a good degree of attachment and penetration throughout both networks. Lactate Dehydrogenase (LDH) and TNF-α releases were used as indicators of cytotoxicity and inflammatory responses respectively. LDH release indicated similar levels of monocyte viability when in contact with the 444 and 316L fibre networks. Both networks elicited a low level secretion of TNF-α, which was significantly lower than that of the positive control wells containing zymosan. Collectively, the results suggest that 444 ferritic and 316L austenitic networks induced similar cytotoxic and inflammatory responses from human monocytes. © 2012 Materials Research Society.

Item Type: Article
Subjects: UNSPECIFIED
Divisions: Div C > Materials Engineering
Div C > Biomechanics
Depositing User: Cron Job
Date Deposited: 07 Mar 2014 12:04
Last Modified: 08 Dec 2014 02:18
DOI: 10.1557/opl.2012.745