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Gelatin nanofiber-reinforced alginate gel scaffolds for corneal tissue engineering.

Tonsomboon, K and Strange, DG and Oyen, ML (2013) Gelatin nanofiber-reinforced alginate gel scaffolds for corneal tissue engineering. Conf Proc IEEE Eng Med Biol Soc, 2013. pp. 6671-6674. ISSN 1557-170X

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Abstract

A severe shortage of donor cornea is now an international crisis in public health. Substitutes for donor tissue need to be developed to meet the increasing demand for corneal transplantation. Current attempts in designing scaffolds for corneal tissue regeneration involve utilization of expensive materials. Yet, these corneal scaffolds still lack the highly-organized fibrous structure that functions as a load-bearing component in the native tissue. This work shows that transparent nanofiber-reinforced hydrogels could be developed from cheap, non-immunogenic and readily available natural polymers to mimic the cornea's microstructure. Electrospinning was employed to produce gelatin nanofibers, which were then infiltrated with alginate hydrogels. Introducing electrospun nanofibers into hydrogels improved their mechanical properties by nearly one order of magnitude, yielding mechanically robust composites. Such nanofiber-reinforced hydrogels could serve as alternatives to donor tissue for corneal transplantation.

Item Type: Article
Uncontrolled Keywords: Alginates Animals Bioprosthesis Cornea Gelatin Glucuronic Acid Hexuronic Acids Humans Hydrogels Nanofibers Tissue Engineering
Subjects: UNSPECIFIED
Divisions: Div C > Biomechanics
Depositing User: Cron Job
Date Deposited: 07 Mar 2014 11:46
Last Modified: 30 Jun 2014 01:08
DOI: 10.1109/EMBC.2013.6611086

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