CUED Publications database

Nanotubes complexed with DNA and proteins for resistive-pulse sensing

Sha, J and Hasan, T and Milana, S and Bertulli, C and Bell, NAW and Privitera, G and Ni, Z and Chen, Y and Bonaccorso, F and Ferrari, AC and Keyser, UF and Huang, YYS (2013) Nanotubes complexed with DNA and proteins for resistive-pulse sensing. ACS Nano, 7. pp. 8857-8869. ISSN 1936-0851

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We use a resistive-pulse technique to analyze molecular hybrids of single-wall carbon nanotubes (SWNTs) wrapped in either single-stranded DNA or protein. Electric fields confined in a glass capillary nanopore allow us to probe the physical size and surface properties of molecular hybrids at the single-molecule level. We find that the translocation duration of a macromolecular hybrid is determined by its hydrodynamic size and solution mobility. The event current reveals the effects of ion exclusion by the rod-shaped hybrids and possible effects due to temporary polarization of the SWNT core. Our results pave the way to direct sensing of small DNA or protein molecules in a large unmodified solid-state nanopore by using nanofilaments as carriers. © 2013 American Chemical Society.

Item Type: Article
Divisions: Div B > Solid State Electronics and Nanoscale Science
Div C > Biomechanics
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:07
Last Modified: 04 Mar 2021 03:55
DOI: 10.1021/nn403323k