CUED Publications database

Network reconstruction using knock-out and over-expression data

Hayden, D and Yuan, Y and Goncalves, J (2013) Network reconstruction using knock-out and over-expression data. 2013 European Control Conference, ECC 2013. pp. 3627-3632.

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This paper outlines necessary and sufficient conditions for network reconstruction of linear, time-invariant systems using data from either knock-out or over-expression experiments. These structural system perturbations, which are common in biological experiments, can be formulated as unknown system inputs, allowing the network topology and dynamics to be found. We assume that only partial state measurements are available and propose an algorithm that can reconstruct the network at the level of the measured states using either time-series or steady-state data. A simulated example illustrates how the algorithm successfully reconstructs a network from data. © 2013 EUCA.

Item Type: Article
Divisions: Div F > Control
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:16
Last Modified: 19 Aug 2021 04:49
DOI: doi:10.23919/ecc.2013.6669768