CUED Publications database

Measuring the compressive viscoelastic mechanical properties of human cervical tissue using indentation.

Yao, W and Yoshida, K and Fernandez, M and Vink, J and Wapner, RJ and Ananth, CV and Oyen, ML and Myers, KM (2014) Measuring the compressive viscoelastic mechanical properties of human cervical tissue using indentation. J Mech Behav Biomed Mater, 34. pp. 18-26.

Full text not available from this repository.

Abstract

The human cervix is an important mechanical barrier in pregnancy which must withstand the compressive and tensile forces generated from the growing fetus. Premature cervical shortening resulting from premature cervical remodeling and alterations of cervical material properties are known to increase a woman׳s risk of preterm birth (PTB). To understand the mechanical role of the cervix during pregnancy and to potentially develop indentation techniques for in vivo diagnostics to identify women who are at risk for premature cervical remodeling and thus preterm birth, we developed a spherical indentation technique to measure the time-dependent material properties of human cervical tissue taken from patients undergoing hysterectomy. In this study we present an inverse finite element analysis (IFEA) that optimizes material parameters of a viscoelastic material model to fit the stress-relaxation response of excised tissue slices to spherical indentation. Here we detail our IFEA methodology, report compressive viscoelastic material parameters for cervical tissue slices from nonpregnant (NP) and pregnant (PG) hysterectomy patients, and report slice-by-slice data for whole cervical tissue specimens. The material parameters reported here for human cervical tissue can be used to model the compressive time-dependent behavior of the tissue within a small strain regime of 25%.

Item Type: Article
Uncontrolled Keywords: Biomechanics Cervix Indentation Viscoelastic Biomechanical Phenomena Cervix Uteri Compressive Strength Elasticity Female Finite Element Analysis Humans Materials Testing Viscosity
Subjects: UNSPECIFIED
Divisions: Div C > Biomechanics
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:06
Last Modified: 23 Nov 2017 04:05
DOI: