CUED Publications database

Cell types, network homeostasis, and pathological compensation from a biologically plausible ion channel expression model.

O'Leary, T and Williams, AH and Franci, A and Marder, E (2013) Cell types, network homeostasis, and pathological compensation from a biologically plausible ion channel expression model. Neuron, 82. pp. 809-821.

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Abstract

How do neurons develop, control, and maintain their electrical signaling properties in spite of ongoing protein turnover and perturbations to activity? From generic assumptions about the molecular biology underlying channel expression, we derive a simple model and show how it encodes an "activity set point" in single neurons. The model generates diverse self-regulating cell types and relates correlations in conductance expression observed in vivo to underlying channel expression rates. Synaptic as well as intrinsic conductances can be regulated to make a self-assembling central pattern generator network; thus, network-level homeostasis can emerge from cell-autonomous regulation rules. Finally, we demonstrate that the outcome of homeostatic regulation depends on the complement of ion channels expressed in cells: in some cases, loss of specific ion channels can be compensated; in others, the homeostatic mechanism itself causes pathological loss of function.

Item Type: Article
Uncontrolled Keywords: Action Potentials Animals Computer Simulation Homeostasis Humans Ion Channels Models, Biological Nerve Net Neurons
Subjects: UNSPECIFIED
Divisions: Div F > Control
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:06
Last Modified: 16 Nov 2017 02:10
DOI: