CUED Publications database

Habenula responses during appetitive and aversive conditioning in major depressive disorder.

Lawson, RP and Nord, CL and Seymour, B and Thomas, DL and Dolan, RJ and Dayan, P and Weiskopf, N and Roiser, JP (2014) Habenula responses during appetitive and aversive conditioning in major depressive disorder. J Neurol Neurosurg Psychiatry, 85. e3-.

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Abstract

The lateral habenula (LHb) has been shown to respond to cues that predict aversive stimuli in non-human primates (Matsumoto & Hikosaka, 2009, Nat Neurosci, 12 (1), 77-84) and has been implicated in reinforcement processing and the pathophysiology of major depression (MDD) (Roiser et al, Biol Psychiatry, 66 (5), 441-450), possibly via reciprocal connections with monoaminergic nuclei. We report the first high-resolution fMRI investigation of haemodynamic responses during appetitive and aversive conditioning in the LHb in unipolar MDD. Additionally, we report the first assessment of tonic habenula function using quantitative Arterial Spin Labelling (ASL) in MDD.

Item Type: Article
Subjects: UNSPECIFIED
Divisions: Div F > Computational and Biological Learning
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 20:02
Last Modified: 18 Nov 2017 21:48
DOI: