CUED Publications database

The habenula encodes negative motivational value associated with primary punishment in humans.

Lawson, RP and Seymour, B and Loh, E and Lutti, A and Dolan, RJ and Dayan, P and Weiskopf, N and Roiser, JP (2014) The habenula encodes negative motivational value associated with primary punishment in humans. Proc Natl Acad Sci U S A, 111. pp. 11858-11863.

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Abstract

Learning what to approach, and what to avoid, involves assigning value to environmental cues that predict positive and negative events. Studies in animals indicate that the lateral habenula encodes the previously learned negative motivational value of stimuli. However, involvement of the habenula in dynamic trial-by-trial aversive learning has not been assessed, and the functional role of this structure in humans remains poorly characterized, in part, due to its small size. Using high-resolution functional neuroimaging and computational modeling of reinforcement learning, we demonstrate positive habenula responses to the dynamically changing values of cues signaling painful electric shocks, which predict behavioral suppression of responses to those cues across individuals. By contrast, negative habenula responses to monetary reward cue values predict behavioral invigoration. Our findings show that the habenula plays a key role in an online aversive learning system and in generating associated motivated behavior in humans.

Item Type: Article
Uncontrolled Keywords: conditioned behavior high-resolution fMRI pallidum Adult Animals Conditioning (Psychology) Cues Female Functional Neuroimaging Habenula Humans Learning Magnetic Resonance Imaging Male Motivation Punishment Reinforcement (Psychology) Species Specificity Young Adult
Subjects: UNSPECIFIED
Divisions: Div F > Computational and Biological Learning
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:05
Last Modified: 21 Sep 2017 01:37
DOI: