CUED Publications database

Antibody landscapes after influenza virus infection or vaccination.

Fonville, JM and Wilks, SH and James, SL and Fox, A and Ventresca, M and Aban, M and Xue, L and Jones, TC and Le, NMH and Pham, QT and Tran, ND and Wong, Y and Mosterin, A and Katzelnick, LC and Labonte, D and Le, TT and van der Net, G and Skepner, E and Russell, CA and Kaplan, TD and Rimmelzwaan, GF and Masurel, N and de Jong, JC and Palache, A and Beyer, WEP and Le, QM and Nguyen, TH and Wertheim, HFL and Hurt, AC and Osterhaus, ADME and Barr, IG and Fouchier, RAM and Horby, PW and Smith, DJ (2014) Antibody landscapes after influenza virus infection or vaccination. Science, 346. pp. 996-1000.

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We introduce the antibody landscape, a method for the quantitative analysis of antibody-mediated immunity to antigenically variable pathogens, achieved by accounting for antigenic variation among pathogen strains. We generated antibody landscapes to study immune profiles covering 43 years of influenza A/H3N2 virus evolution for 69 individuals monitored for infection over 6 years and for 225 individuals pre- and postvaccination. Upon infection and vaccination, titers increased broadly, including previously encountered viruses far beyond the extent of cross-reactivity observed after a primary infection. We explored implications for vaccination and found that the use of an antigenically advanced virus had the dual benefit of inducing antibodies against both advanced and previous antigenic clusters. These results indicate that preemptive vaccine updates may improve influenza vaccine efficacy in previously exposed individuals.

Item Type: Article
Uncontrolled Keywords: Antibodies, Viral Antigenic Variation Evolution, Molecular Humans Influenza A Virus, H3N2 Subtype Influenza Vaccines Influenza, Human Vaccination
Divisions: Div C > Biomechanics
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 18:59
Last Modified: 15 Jun 2018 20:26