CUED Publications database

Multi-scale mechanical response of freeze-dried collagen scaffolds for tissue engineering applications.

Offeddu, GS and Ashworth, JC and Cameron, RE and Oyen, ML (2014) Multi-scale mechanical response of freeze-dried collagen scaffolds for tissue engineering applications. J Mech Behav Biomed Mater, 42. pp. 19-25.

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Abstract

Tissue engineering has grown in the past two decades as a promising solution to unresolved clinical problems such as osteoarthritis. The mechanical response of tissue engineering scaffolds is one of the factors determining their use in applications such as cartilage and bone repair. The relationship between the structural and intrinsic mechanical properties of the scaffolds was the object of this study, with the ultimate aim of understanding the stiffness of the substrate that adhered cells experience, and its link to the bulk mechanical properties. Freeze-dried type I collagen porous scaffolds made with varying slurry concentrations and pore sizes were tested in a viscoelastic framework by macroindentation. Membranes made up of stacks of pore walls were indented using colloidal probe atomic force microscopy. It was found that the bulk scaffold mechanical response varied with collagen concentration in the slurry consistent with previous studies on these materials. Hydration of the scaffolds resulted in a more compliant response, yet lesser viscoelastic relaxation. Indentation of the membranes suggested that the material making up the pore walls remains unchanged between conditions, so that the stiffness of the scaffolds at the scale of seeded cells is unchanged; rather, it is suggested that thicker pore walls or more of these result in the increased moduli for the greater slurry concentration conditions.

Item Type: Article
Uncontrolled Keywords: Colloidal probe AFM Indentation Scaffolds mechanics Type I collagen Viscoelastic Animals Biomechanical Phenomena Cattle Collagen Type I Elasticity Freeze Drying Materials Testing Mechanical Phenomena Membranes, Artificial Tissue Engineering Tissue Scaffolds Viscosity
Subjects: UNSPECIFIED
Divisions: Div C > Biomechanics
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:00
Last Modified: 18 Nov 2017 21:43
DOI: