CUED Publications database

Cooperative contractility: The role of stress fibres in the regulation of cell-cell junctions

Ronan, W and McMeeking, RM and Chen, CS and McGarry, JP and Deshpande, VS (2015) Cooperative contractility: The role of stress fibres in the regulation of cell-cell junctions. Journal of Biomechanics, 48. pp. 520-528. ISSN 0021-9290

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© 2014 Elsevier Ltd. We present simulations of cell-cell adhesion as reported in a recent study [. Liu et al., 2010, PNAS, 107(22), 9944-9] for two cells seeded on an array of micro-posts. The micro-post array allows for the measurement of forces exerted by the cell and these show that the cell-cell tugging stress is a constant and independent of the cell-cell junction area. In the current study, we demonstrate that a material model which includes the underlying cellular processes of stress fibre contractility and adhesion formation can capture these results. The simulations explain the experimentally observed phenomena whereby the cell-cell junction forces increase with junction size but the tractions exerted by the cell on the micro-post array are independent of the junction size. Further simulations on different types of micro-post arrays and cell phenotypes are presented as a guide to future experiments.

Item Type: Article
Uncontrolled Keywords: Cell-cell junctions Junction force Mechanotransduction Myosin contractility Stress fibre Animals Cell Adhesion Cell Communication Cell Physiological Phenomena Computer Simulation Finite Element Analysis Humans Intercellular Junctions Models, Biological Stress Fibers
Divisions: Div C > Materials Engineering
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:44
Last Modified: 15 Sep 2020 04:52
DOI: 10.1016/j.jbiomech.2014.11.025