CUED Publications database

Cooperative contractility: the role of stress fibres in the regulation of cell-cell junctions.

Ronan, W and McMeeking, RM and Chen, CS and McGarry, JP and Deshpande, VS (2014) Cooperative contractility: the role of stress fibres in the regulation of cell-cell junctions. J Biomech, 48. pp. 520-528.

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Abstract

We present simulations of cell-cell adhesion as reported in a recent study [Liu et al., 2010, PNAS, 107(22), 9944-9] for two cells seeded on an array of micro-posts. The micro-post array allows for the measurement of forces exerted by the cell and these show that the cell-cell tugging stress is a constant and independent of the cell-cell junction area. In the current study, we demonstrate that a material model which includes the underlying cellular processes of stress fibre contractility and adhesion formation can capture these results. The simulations explain the experimentally observed phenomena whereby the cell-cell junction forces increase with junction size but the tractions exerted by the cell on the micro-post array are independent of the junction size. Further simulations on different types of micro-post arrays and cell phenotypes are presented as a guide to future experiments.

Item Type: Article
Uncontrolled Keywords: Cell-cell junctions Junction force Mechanotransduction Myosin contractility Stress fibre Animals Cell Adhesion Cell Communication Cell Physiological Phenomena Computer Simulation Finite Element Analysis Humans Intercellular Junctions Models, Biological Stress Fibers
Subjects: UNSPECIFIED
Divisions: Div C > Materials Engineering
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:44
Last Modified: 17 Nov 2017 20:19
DOI: