CUED Publications database

Meiotic recombination hotspots - a comparative view.

Choi, K and Henderson, IR (2015) Meiotic recombination hotspots - a comparative view. Plant J, 83. pp. 52-61.

Full text not available from this repository.


During meiosis homologous chromosomes pair and undergo reciprocal genetic exchange, termed crossover. Meiotic recombination has a profound effect on patterns of genetic variation and is an important tool during crop breeding. Crossovers initiate from programmed DNA double-stranded breaks that are processed to form single-stranded DNA, which can invade a homologous chromosome. Strand invasion events mature into double Holliday junctions that can be resolved as crossovers. Extensive variation in the frequency of meiotic recombination occurs along chromosomes and is typically focused in narrow hotspots, observed both at the level of DNA breaks and final crossovers. We review methodologies to profile hotspots at different steps of the meiotic recombination pathway that have been used in different eukaryote species. We then discuss what these studies have revealed concerning specification of hotspot locations and activity and the contributions of both genetic and epigenetic factors. Understanding hotspots is important for interpreting patterns of genetic variation in populations and how eukaryotic genomes evolve. In addition, manipulation of hotspots will allow us to accelerate crop breeding, where meiotic recombination distributions can be limiting.

Item Type: Article
Uncontrolled Keywords: DNA motifs chromatin hotspots meiosis recombination Crossing Over, Genetic DNA Breaks, Double-Stranded DNA, Single-Stranded Epigenesis, Genetic Fungi Genetic Techniques Genome Homologous Recombination Meiosis Plants
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 18:57
Last Modified: 21 Jun 2018 02:38